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T. A. Bogush, I. A. Mamichev, I. P. Borisenko, E. A. Bogush, N. O. Vichlzantseva, V. J. Kirsanov
The assessment
of diploid cells in G0/G1 cell cycle-phases
in ovarian cancer tissue by flow cytometry
Abstract
A quantitative assessment of the diploid cell
fraction in G0/G1 phases of cell cycle was
performed by flow cytometry method (60 surgery specimens of ovarian cancer
stage III). It was shown that the distribution of tumoral diploid cell numbers
in G0/G1 was widely dispersed, from 27 up
to 95% with the median of 73%. Significant differences between tumor samples of
patients sensitive to the first line platinum/taxanes chemotherapy and patients
resistant to it were observed (p = 0,002). The predictive value of G0/G1
fraction has been concluded, quantitative assessment of the fraction is
recommended for clinical usage.
Key words:
fraction of diploid cells G0/G1, predictive
value, platinum/taxanes chemotherapy, ovarian cancer, recurrence period, flow
cytometry.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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