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T. A. Bogush, S. A. Kalyuzhny, M. R. Chetyrkina, M. A. Yastrebova, A. M. Scherbakov, O. M. Ryabinina, I. A. Mamichev, E. A. Bogush, A. A. Kamensky
Molecular
mechanisms of drug resistance in MCF7/ADR BREAST CANCER CELLS
Abstract
It was revealed
differences between expression of vimentin and P-gp in sensitive MCF7 and
resistant MCF7/ADR cells thus demonstrating the “coexistence” of two drug
resistance mechanisms in MCF7/ADR cells. Mesenchymal phenotype of epithelial
cells contributes significantly to resistance mechanism in comparison with
overexpression of the ABC-transporter the difference in vimentin expression
levels between sensitive and resistant cell cultures is substantially higher
compared with the difference in P-gp expression levels..
Key words: MCF7,
MCF7/ADR, breast cancer cell cultures, drug resistance,
epithelial-to-mesenchymal transition, vimentin, P-gp, flow cytometry.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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