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D. V. Barkhova, M. S. Andrianova, N. V. Komarova, A. E. Kuznetsov

Channel and motor proteins for translocation of nucleic acids in nanopore sequencing technology


In the process of nanopore sequencing, the primary structure of the analyzed DNA or RNA is decrypted by translocation of a nucleic acid molecule through a nanopore intercalated into the membrane. A nanopore is a protein transmembrane channel that is permeable to water, low molecular weight ions, and single-stranded DNA or RNA. This review discusses the channel proteins used in nanopore sequencing, their modifications, as well as assisting proteins that regulate the process of nucleic acid translocation.
Key words: coa: nanopore sequencing, organic nanopore, transmembrane protein, motor protein.
Moscow University Chemistry Bulletin.
2020, Vol. 61, No. 3, P. 187

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