ChemNet
 
Previous article Next article Contents  

D. V. Barkhova, M. S. Andrianova, N. V. Komarova, A. E. Kuznetsov

Channel and motor proteins for translocation of nucleic acids in nanopore sequencing technology

Abstract

In the process of nanopore sequencing, the primary structure of the analyzed DNA or RNA is decrypted by translocation of a nucleic acid molecule through a nanopore intercalated into the membrane. A nanopore is a protein transmembrane channel that is permeable to water, low molecular weight ions, and single-stranded DNA or RNA. This review discusses the channel proteins used in nanopore sequencing, their modifications, as well as assisting proteins that regulate the process of nucleic acid translocation.
Key words: coa: nanopore sequencing, organic nanopore, transmembrane protein, motor protein.
Moscow University Chemistry Bulletin.
2020, Vol. 61, No. 3, P. 187
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
   Overview
   Editorial board
   Tables of Contents
   Subscription

The site is supported by Russian Foundation for Basic Research
  The using of published on this page materials is not allowed without special permission
Copyright (C) Chemisty Department of Moscow State University
Web-Editor: B.I.Pokrovskii
Web-design: Copyright (C) MIG and VVM
webmaster@www.chem.msu.su