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K. S. Trosheva, S. A. Sorokina, A. A. Efimova
The interaction of anionic liposomes with
cationic pyridylphenylene dendrimers
Abstract
Complexes of cationic pyridylphenylene
dendrimers with solid and liquid anionic liposomes were obtained. Adsorption of
a dendrimer on the surface of liposomes is accompanied by neutralization of
their surface charge and an increase in particle size. When interacting with
liquid liposomes, the dendrimer does not induce the transition of molecules of
a negatively charged lipid from the internal to the external monolayer
(flip-flop). In the complex, there are about 80 dendrimer molecules per
liposome.
Key words: liposome, polycation, dendrimer,
binding.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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