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S. A. Yagubov, G. M. Yankovskii, S. E. Kondakov

Study of distribution of metronidazole in rectum cancer tissue in an in vivo experiment in case of administration of the drug via rectal application

Abstract

Distribution of metronidazole in rectum cancer tissue and proximal healthy tissue was studied in the case of administration of the drug via rectal application. Concentration of metronidazole in extracts from tumor tissue and the proximal healthy tissue was studied by the means of UV - spectrophotometry. The comparative analysis of pharmacokinetics of metronidazole in the malignant and healthy proximal tissue depending on the initial concentration of metronidazole in the composition applied rectally based on 31 cases in 341 tissue samples was carried out.
Key words: metronidazole, UV-spectrophotometry, cancer tissue, bioavailability , in vivo experiment.
Moscow University Chemistry Bulletin.
2016, Vol. 57, No. 5, P. 336
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
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