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Yu. N. Morozov, V. V. Fedorov, V. P. Shabatin, O. I. Vernaya, V. V. Chernyshev, A. S. Abel, I. V. Arhangel’skii, T. I. Shabatina, G. B. Sergeev
Cryochemical
modification of drugs: nanosized form III of piroxicam and its physico-chemical
properties
Abstract
By
using dynamic sublimation in a stream of heated carrier gas and low temperature
condensation is carried out structurally –nanoscale modification of
anti-inflammatory drug substances
4-hydroxy-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazin-3-carboxamide
1,1-dioxide (piroxicam). Thus obtained samples correspond to the known
thermodynamically metastable form III of piroxicam. The average size of the
particles of the drug are dmid = 300±30 nm. Obtained nanoform
of piroxicam does not undergo structural and aggregation transformations for at
least four years.
Key words: organic
nanoparticles, cryochemical modification, polymorphism of drugs, crystal
modifications, piroxicam.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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