M. A. Orlova, T. P. Trofimova, S. V. Nikulin, A. P. Orlov
The relationship between NO-synthase
inhibitory activity of N-, S- containing heterocycles with their
radioprotective and antileukemic properties
The impact of NO-synthase (NOS) inhibitors,
and activator for leukemic cell line HL-60, K-562, MOLT-4 andbone
marrow cells of untreated patients diagnosed with acute B-lymphoblastic
leukemia, compared with lymphocytes from healthy donors was examined. The data
about the relationship of radioprotective, NOS-inhibitory and cytotoxic
properties of a number of derivatives of thiazine, thiazoline and thiourea
testify about the possibility of their potential useas agents for
complex radio- and chemotherapy.
Key words: acute leukemia; derivatives of
thiazoline, thiazine and thiourea; NO-synthase inhibitors, radioprotectors.
Copyright (C) Chemistry Dept., Moscow State University, 2002