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E. A. Zaitseva, Yu. I. Golovin, O. A. Kost, I. I. Nikol’skaya, K. Yu. Vlasova, L. Yu. Filatova, A. B. Belova, E. N. Efremenko, I. V. Lyagin, A. D. Aleksashkin, N. V. Nukolova, A. G. Majouga, A. V. Kabanov, N. L. Klyachko

"NANOZYME" technology in Moscow university. achievements and development perspectives


Novel functional bionanosystems developed in the Lomonosov Moscow State University laboratory “Chemical design of bionanomaterials” in collaboration with scientists from UNC Eshelman School of Pharmacy (USA) for therapy and diagnostics based on proteins, enzymes, polymeric coatings, magnetic nanoparticles are presented in the review. The properties of enzymes (superoxide dismutase, catalase, organophosphate hydrolase, lysines of bacteriophages) and other drugs molecules immobilized in polymeric complexes as well as the methods for targeted drug delivery using cell-mediated systems and magnetic nanoparticles and operating conditions in vitro and in vivo are discussed. Physical and chemical characteristics including function peculiarities data of the nanoformulations are obtained. The nanoformulations developed demonstrated high potential therapeutic efficacy for treatment of central nervous system and brain diseases, inflammations (including inflammatory diseases in the eye), cancer and infectious diseases, neurotoxic injury and others. The possibilities of remote control biochemical reactions using a non-heating low-frequency alternating magnetic field (AMF) for the controlled release of drugs are analyzed in the review. The experimental results of the AMF effects on bionanosystems containing magnetic nanoparticles such as changing the catalytic activities of enzymes bound to magnetic nanoparticles as well as “disordering” of lipid bilayer in membranes are considered.
Key words: nanomedicine, enzymes, block copolymers, nanozymes, targeted drug delivery, theranostics, functionalized magnetic nanoparticles, low-frequency alternating magnetic field, controlled release of drugs.
Moscow University Chemistry Bulletin.
2016, Vol. 57, No. 4, P. 211

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