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L. V. Avdeeva, V. K. Koltover

Nuclear spin catalysis in living nature


In chemistry, there is the so-called magnetic isotope effect: the reactions show different rates and different yields of products according to whether the reagents contain magnetic or nonmagnetic isotopes. Our group has first performed the experiments with cells enriched with different stable isotopes of magnesium, magnetic 25Mg versus nonmagnetic 24Mg or 26Mg. It was revealed that adaptation of bacteria E. coli to the growth media, enriched with magnetic 25Mg, proceeds faster as compared to the growth media, enriched with nonmagnetic 24Mg or 26Mg. Furthermore, with another commonly accepted cell model, yeast S. cerevisiae, it was revealed that the rate constant of post-radiation recovery of the cells after UV irradiation is twice higher for the cells enriched with 25Mg than for the cells enriched with the nonmagnetic isotope. In collaboration with Ukrainian colleagues from Palladin Institute of Biochemistry in Kiev, the effects of different isotopes of magnesium on ATP hydrolysis driven by myosin isolated from myometrium were studied. The enzyme activity has turned out to be 2.02.5 times higher in the reaction media enriched with 25Mg as compared to the activity of the same enzyme in the reaction media enriched with the spinless 24Mg or 26Mg. Some possible mechanisms of the magnetic isotope effects (nuclear spin catalysis) in the biological objects are discussed.
Key words: biocatalysts, nuclear spin catalysis, stable isotopes, magnetic-isotope effect, reliability.
Moscow University Chemistry Bulletin.
2016, Vol. 57, No. 3, P. 145

Copyright (C) Chemistry Dept., Moscow State University, 2002
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