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A. V. Pirogov, E. B. Pashkova, A. A. Bendryshev, R. V. Ulyanov, O. A. Shpigun
Determination
of mitomycin-C in urinary bladder at surface cancer therapy
Abstract
A technique of the quantitative determination of mitomicin-C in
bladder core by a method of gradient high performance liquid chromatography
with a mass-spectrometric detection in an electrospray mode of ionization was
developed. A range of linearity of the calibration plot is 20 to 400 ppb.
The limit of the detection is 15 ppb. A sampling procedure, including a single
extraction by water allow the quantitatively determination of mitomicin-C. The
proposed technique was used for the determination of mitomicin-C in the real
samples of human bladder.
Key words: microemulsion liqiud chromatography, mitomicin-C.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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