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L. I. Korolenkova, E. V. Stepanova, V. D. Ermilova, A. U. Barishnikov, V. V. Bryusgin

e-cadherin expression is biochemical marker in cervical intraepithelial neoplasia


The original paper contains the results of immunohistochemical studies on e-cadherin expression in cervical intraepithelial neoplasia. To evaluate the quantitative expression was used avidin-biotin peroxidase method. Cervical intraepithelial neoplasias (CIN) are the lesions that for some years precede invasive cervical cancer. CIN outcomes are variable in terms of regression and progression rates. E-cadherin expression was tested in cervical tissues of CIN patients (81 sample) and HPV-infected women with no CIN (10 samples). Significant e-cadherin down-regulation was revealed in CIN3 samples in compare to CIN1-2 and "normal" epithelium. The marker should be considered as a useful tool in CIN grade assessment and individual outcome prognosis. These data open the way for the creation of new pharmaceuticals based on the search for compounds that affect the expression of e-cadherin.
Key words: CIN, e-cadherin, progression markers, cervical cancer.
Moscow University Chemistry Bulletin.
2012, Vol. 53, No. 4, P. 272

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