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I. G. Smirnova, G. N. Gildeeva, V. V. Chistyakov

Analysis of crystalline structure and chirality of drug substances


The change in substance’s crystalline state or chirality influence on physical and chemival, pharmacotechnological features as well as bioavailability of pharmaceuticals. It was identified that such methods as X-Ray Powder Diffraction, infrared Fourier transform spectroscopy, differential scanning calorimetry, optical microscopy, circular dichroism can be successfully used for quality control of medical preparation.
Key words: drags, polymorphism of drag substances, polymorphic modification, assay, UV-spectroscopy, optical isomerism, circular dichroism.
Moscow University Chemistry Bulletin.
2012, Vol. 53, No. 4, P. 234

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