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A. V. Severin, G. A. Badun, M. G. Chernysheva

Studying the nature of interaction between nanohydroxyapatite and albumins by radionu clide-microscopy diagnostics


Multistage character of adsorption isotherms of human and bovine serum albumins on hydroxyapatite nanoparticles from aqueous solution have been developed by radionuclide-microscopy method. Such isotherms character indicated the number of physicalchemical processes: formation of the peptide-nanohydroxyapatite complex and following by aggregation in liquid and solid phases. This hypothesis was confermed by X-ray and dynamic light-scattering analysis. It was shown, that when hydroxyapatite is formed in albumin solution the peptide-nanohydroxyapatite complex formation is followed by morphology and structure exchange of hydroxyapatite nanocrystals.
Moscow University Chemistry Bulletin.
2011, Vol. 52, No. 6, P. 449

Copyright (C) Chemistry Dept., Moscow State University, 2002
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