A. V. Severin, G. A. Badun, M. G. Chernysheva
Studying the nature of interaction between
nanohydroxyapatite and albumins by radionu clide-microscopy diagnostics
Multistage character of adsorption
isotherms of human and bovine serum albumins on hydroxyapatite nanoparticles
from aqueous solution have been developed by radionuclide-microscopy method.
Such isotherms character indicated the number of physicalchemical processes:
formation of the peptide-nanohydroxyapatite complex and following by aggregation
in liquid and solid phases. This hypothesis was confermed by X-ray and dynamic
light-scattering analysis. It was shown, that when hydroxyapatite is formed in
albumin solution the peptide-nanohydroxyapatite complex formation is followed
by morphology and structure exchange of hydroxyapatite nanocrystals.
Copyright (C) Chemistry Dept., Moscow State University, 2002