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B. M. Sergeev, S. P. Mikhalev, Yu. N. Morosov, V. P. Shabatin, P. N. Kolotilov, G. B. Sergeev
Cryochemical Modification of
Drug Substances:
Micronized Amorphous Form of
Carvedilol
Abstract
X-ray amorphous form of drug substance carvedilol – (±)
1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol has been
obtained by cryochemical modification method including vaporization of
substance in of hot carrier gas flow and followed vapor condensation on surface
cooled down to the temperature of liquid nitrogen boiling (-196°C). Cryomodification
along with amorphous phase formation lead to micronization – substance
particles size decrease from the initial 5–10 down to 1–2 mm.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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