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Ye. A. Alyamkina, S. A. Yamashkin, N. N. Artayeva, M. A. Yurovskaya
On the possibility of using
4-amino-2-phenyl- and 4-amino-1-methyl-2-phenylindoles
in the synthesis of pyrroloquinolines according
to Combes
Abstract
The reaction of 4-amino-2-phenyl- and
4-amino-1-methyl-2-phenylindoles with free b-position
of pyrrole ring with acetylacetone and dibenzoilmethane has been studied. It
has been ascertained that primary condensation is realized only upon
aminogroups and produces the corresponding enaminoketones. Under conditions of
enamines acidic cyclization on basis of dibenzoylmethane turn into pyrrolo[2,3-h]quinolines. The products of cyclization
with participation of indole C3 atom has not been
detected.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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