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Yu. N. Morozov, S. P. Mikhalev, V. P. Shabatin, P. N. Kolotilov, G. B. Sergeev

Cryomodification of drugs: micronization and crystalline structures of 1-(aminomethyl)-cyclohexaneacetic acid


Cryochemical modification is a method of micronization and changing of crystalline structure of organic substances, that in application to drug substations may lead to the improvement of thiere biopharmacological properties. The method was successfully developed for chemically labile compound named gabapentine [1-(aminomethyl)-cyclohexaneacetic acid]. According to the data obtained by X-ray diffraction, FTIR-spectroscopy, and differentiall scanning calorimetry (DSC), the formation of two kinetically stable polymorphic modification of gabapentine (forms with melting points 157 C and 163C), which are differ from initial commercial one (with a melting point 153C), was observed. These two forms are known but advantage of present work is in developing the new method of their production excluding the use of any solvents, that is very important for environmental safety.
Moscow University Chemistry Bulletin.
2010, Vol. 51, No. 4, P. 288

Copyright (C) Chemistry Dept., Moscow State University, 2002
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