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A. N. Savchenko V. A. Ol’shevskaya, V. N. Kalinin, A. A. Shtil

Boronated derivatives of protohemin IX and l-amino acids as potential anticancer agents

Abstract

We synthesized a series of novel water soluble conjugates of protohemin IX with anionic 1-carba-closo-dodecaborate and L-amino acids. In these compounds the amino acid residues are bound to the porphyrin macrocycle via the amide or ester bonds. The antitumor activity of novel compounds demonstrated their high potency in killing a variety of human tumor cell lines, including those that expressed molecular determinants of altered anticancer drug response.
Moscow University Chemistry Bulletin.
2007, Vol. 48, No. 5, P. 292
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
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