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E. M. Rekharsky, T. V. Polenova, A. G. Borzenko
Phosphorescence of some naphthalene
derivative drugs in water media
Abstract
The sensitivity of room temperature
phosphorimetry (RTP) makes it useful analytical tool for monitoring compounds
of biochemical interest such as drugs. In the present paper, RTP spectra of
three compounds with closely overlapping spectra: nafronyl, naphazoline and
propranolol produced by organized medium such as cyclodextrins (CD-RTP) and by
heavy atoms without protective media were analyzed. The use of phosphorescence
enhancers (external heavy atoms) and sodium sulfite (deoxygenation agent) were
studied and optimized. The best working conditions in the investigated systems
were proposed for the determination of each component alone and in mixture. The
qualities and limitations of each system are discussed. Time-resolved room temperature phosphorimetry have
provided a convenient means for analyzing mixture of investigated drugs.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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