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A. S. Romanenkov, O. A. Borisova, E. A. Kubareva, T. S. Oretskaya, V. G. Metelev

Synthesis and properties of oligodesoxyribonucleotides containing phosphoryldisulfide moiety in the predetermined position of carbohydrate-phosphate backbone

Abstract

The synthesis of oligodeoxyribonucleotides with internucleotide phosphoryldithio group was optimized. The lowering of incubation mixture pH to 4.5 - 5.0 allowed to lessen substantively the reaction time and to increase the yield of target compounds. It was demonstrated that modified oligodeoxyribonucleotides are able to interact easily with mercapto groups of dithiotreitol and cysteine via thiol-disulfide exchange, but they are stable to lysine treatment.
Moscow University Chemistry Bulletin.
2003, Vol. 44, No. 3, P. 208
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
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