Previous article Next article Contents  

A. S. Romanenkov, O. A. Borisova, E. A. Kubareva, T. S. Oretskaya, V. G. Metelev

Synthesis and properties of oligodesoxyribonucleotides containing phosphoryldisulfide moiety in the predetermined position of carbohydrate-phosphate backbone


The synthesis of oligodeoxyribonucleotides with internucleotide phosphoryldithio group was optimized. The lowering of incubation mixture pH to 4.5 - 5.0 allowed to lessen substantively the reaction time and to increase the yield of target compounds. It was demonstrated that modified oligodeoxyribonucleotides are able to interact easily with mercapto groups of dithiotreitol and cysteine via thiol-disulfide exchange, but they are stable to lysine treatment.
Moscow University Chemistry Bulletin.
2003, Vol. 44, No. 3, P. 208

Copyright (C) Chemistry Dept., Moscow State University, 2002
   Editorial board
   Tables of Contents

The site is supported by Russian Foundation for Basic Research
  The using of published on this page materials is not allowed without special permission
Copyright (C) Chemisty Department of Moscow State University
Web-Editor: B.I.Pokrovskii
Web-design: Copyright (C) MIG and VVM